Is inflammatory micronucleation the key to a successful anti-mitotic cancer drug?
نویسندگان
چکیده
منابع مشابه
Is inflammatory micronucleation the key to a successful anti-mitotic cancer drug?
Paclitaxel is a successful anti-cancer drug that kills cancer cells in two-dimensional culture through perturbation of mitosis, but whether it causes tumour regression by anti-mitotic actions is controversial. Drug candidates that specifically target mitosis, including inhibitors of kinesin-5, AurkA, AurkB and Plk1, disappointed in the clinic. Current explanations for this discrepancy include p...
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ژورنال
عنوان ژورنال: Open Biology
سال: 2017
ISSN: 2046-2441
DOI: 10.1098/rsob.170182